Bratislava Medical Journal Vol.113, No.7, p.404–408, 2012
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Title: Uncommon leukemic case of anaplastic large cell lymphoma diagnosed through a typical chromosomal abnormality t(2;5) with a null phenotype and aberrant expression of NG2 and CD13 |
Author: A. Kolenova, E. Mejstrikova, K. Fidlerova, E. Fronkova, L. Plank, P. Szepe, J. Jindrova, D. Sejnova, A. Zakovicova, E. Kaiserova |
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Abstract: Anaplastic large cell lymphoma represents approximately 10–15 % of pediatric non-Hodgkin lymphomas. Leukemic presentation is very rare, and in particular, the null phenotype ALCL without typical anaplastic morphology together with aberrant expression of CD13 and/or CD11b represents a diagnostic challenge. We report a case of a 9 year-old boy with leukemic presentation of ALCL with the typical translocation t(2;5)(p23;q35); in this patient, the only positive antigens identified by immunophenotyping were CD13, NG2 HLA-DR, and CD38. To our knowledge, aberrant expression of NG2 has never been reported in ALCL cases (Tab. 1, Fig. 6, Ref. 20)
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Keywords: anaplastic large cell lymphoma, NG2 – chondroitin sulphate proteoglycan neuron-glial antigen 2, ALK- anaplastic lymphoma kinase protein |
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Year: 2012, Volume: 113, Issue: 7 |
Page From: 404, Page To: 408 |
doi:10.4149/BLL_2012_091
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