Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.8, p.471–475, 2012

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.113, No.8, p.471–475, 2012

Title: Myostatin downregulates the expression of basic fibroblast growth factor gene in HeLa cells
Author: H. Z. Liu, P. Luo, S. H. Chen, J. H. Shang

Abstract: Basic fibroblast growth factor (bFGF or FGF-2), a potent tumorigenic cytokine, improves cells proliferation and angiogenesis in tumor and also plays vital roles in tumor growth, metastasis as well as prognosis. Screening and application of effective cytokines against bFGF tumorigenic activity would be helpful to oncologic therapy. Myostatin, a member of transforming growth factor β superfamily, recently showed an antitumor activity and was reported to induce HeLa cells apoptosis through mitochondrion pathway. The above data raised our assumption that expression level of endogenous bFGF gene may be suppressed by exogenous myostatin in myostatin-treated HeLa cells. To test the hypothesis, myostatin was employed to stimulate HeLa cells and expressional level of endogenous bFGF gene in HeLa cells was detected with real-time RT-PCR and ELISA. Results of the suppressed expression level of bFGF gene in Hela cells implied that myostatin may be regarded as an effective cytokine against bFGF to treat certain cancers (Fig. 3, Ref. 26).

Keywords: myostatin, basic fibroblast growth factor, HeLa cells.
Year: 2012, Volume: 113, Issue: 8 Page From: 471, Page To: 475
doi:10.4149/BLL_2012_104


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