Home General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.3, p.255-260, 2012

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.31, No.3, p.255-260, 2012

Title: Role of fenofibrate in restoring angiogenesis in diabetic and control hind limb ischemic rats
Author: Ensieh Salehi, Majid Khazaei, Bahman Rashidi

Abstract:

In this study, we examined the effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor α (PPARα), on angiogenesis and serum nitric oxide (NO), vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) in diabetic and control hind limb ischemic rats. Male Wistar rats underwent left hind limb ischemia. The experimental groups consisted of rats: control, diabetic, control receiving fenofibrate (100 mg/kg/day, by gavage) and diabetic receiving fenofibrate. After 21 days, blood samples were taken and capillary density and capillary/fiber ratio of the ischemic hind limb muscle was evaluated by immunohistochemistry.

Activation of PPARα by fenofibrate restored neovascularization in diabetic and control hind limb ischemic rats (p < 0.05).

Fenofibrate administration significantly increased serum nitrite concentration, the main metabolite of NO, without significant changes in serum VEGF and VEGFR-2 concentrations. It seems that fenofibrate enhances angiogenesis in hind limb ischemia possibly through increasing of NO bioavailability and can be considered for treatment of diabetic peripheral vascular diseases in future human studies.



Keywords: Diabetes — Hind limb ischemia — Fenofibrate — Angiogenesis — Nitric oxide
Year: 2012, Volume: 31, Issue: 3 Page From: 255, Page To: 260
doi:10.4149/gpb_2012_033


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