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Neoplasma Vol.60, No.2, p.123-128, 2013 |
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Title: Expression of NRF2 and NRF2-modulated genes in peripheral blood leukocytes of bladder cancer males | ||
Author: E. RESZKA, Z. JABLONOWSKI, E. WIECZOREK, J. GROMADZINSKA, E. JABLONSKA, M. SOSNOWSKI, W. WASOWICZ | ||
Abstract: Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is an oxidant-responsive transcription factor involved in induction of antioxidant genes. We assessed NRF2 and selected NRF2-modulated gene expression: glutathione S-transferase A1 and P1 (GSTA1 and GSTP1), mitochondrial superoxide dismutase (SOD2) in blood leukocytes of 51 bladder cancer patients and 90 control males. A significant up-regulation of SOD2 expression (P=0.002) was observed in leukocytes of patients. NRF2 expression was positively correlated with GSTP1 and with SOD2 mRNA level, both in patients and controls. |
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Keywords: NRF2, antioxidant gene expression, bladder cancer, leukocytes | ||
Published online: 26-Nov-2012 | ||
Year: 2013, Volume: 60, Issue: 2 | Page From: 123, Page To: 128 | |
doi:10.4149/neo_2013_016 |
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