Home Neoplasma 2013 Neoplasma Vol.60, No.3, p.290-294, 2013

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.60, No.3, p.290-294, 2013

Title: Distant metastasis in triple-negative breast cancer
Author: L. M. TSENG, N. C. HSU, S. C. CHEN, Y. S. LU, C. H. LIN, D. Y. CHANG, H. LI, Y. C. LIN, H. K. CHANG, T. C. CHAO, F. OUYANG, M. F. HOU

Abstract: Triple-negative breast cancer (TNBC) relapses more frequently than hormone receptor-positive subtypes and is often associated with poor outcomes. This retrospective study reviewed the pattern of distant metastasis with regard to survival in patients with TNBC. A total of 205 TNBC patients were analyzed. TNBC patients with lung metastases had the longest median post-metastatic OS (with 95% confidence interval) of 16.6 (10.3-22.9) months, followed by the bone, 16.3 (11.7-20.8) months, the liver, 8.9 (3.5-14.4) months, the pleura, 7.5 (2.8-12.3) months, and the brain, 4.3 (0.6-8.0) months. Kaplan-Meier plots indicated that TNBC patients with metastatic spread to brain, liver, and pleural had poorer post-metastatic OS rate than patients with lung metastases (p = 0.001, 0.004, and 0.029, respectively). Moreover, brain and liver metastases correlated significantly with poorer post-metastatic OS as compared to bone metastasis (p = 0.004 and 0.011, respectively). Route of first metastasis correlated significantly with survival of TNBC patients with brain metastases being the poorest survival indicator, followed by metastases to liver, pleura, bone, and lung.

Keywords: triple-negative breast cancer, metastasis, survival
Published online: 30-Jan-2013
Year: 2013, Volume: 60, Issue: 3 Page From: 290, Page To: 294

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