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Bratislava Medical Journal Vol.114, No.4, p.199–205, 2013 |
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Title: The impact of thiopurine-S-methyltransferase genotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases | ||
Author: T. Hlavaty, M. Batovsky, D. Balakova, I. Pav, P. Celec, M. Gregus, M. Zakuciova, M. Hlista, M. Horakova, B. Desatova, T. Koller, J. Toth, L. Kadasi, M. Huorka | ||
Abstract: Background and aims: The thiopurine drugs, azathioprine (AZA) and 6-mercaptopurine, are established in the treatment of inflammatory bowel diseases (IBD). Polymorphisms in thiopurine S-methyltransferase (TPMT) gene have been associated with adverse drug reactions (ADRs) to AZA.
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Keywords: inflammatory bowel diseases, Crohn’s disease, ulcerative colitis, therapy, azathioprine, 6-mercaptopurine, thiopurine-S-methyltransferase, polymorphisms, adverse drug reaction | ||
Year: 2013, Volume: 114, Issue: 4 | Page From: 199, Page To: 205 | |
doi:10.4149/BLL_2013_042 |
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