Home Neoplasma 2013 Neoplasma Vol.60, No.4, p.355-363, 2013

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.60, No.4, p.355-363, 2013

Title: The effect of prolactin and estrogen cross-talk on prolidase– dependent signaling in MCF-7 cells
Author: A. Surazynski, W. Miltyk, S. Wolczynski, J. Palka

Abstract: Estrogen and prolactin play important role in mammary carcinogenesis. The present study was undertaken to evaluate the effect of prolactin and estrogen cross-talk on HIF-1 α level and expression of some HIF-1 α - dependent signaling proteins. Since up-regulation of prolidase activity inhibits HIF-1 α degradation, the enzyme was considered as an interface of estrogen/prolactin signaling. The experiments were performed on MCF-7 cells cultured with prolactin in the presence or absence of estradiol. It was found that in the presence of estradiol, prolactin inhibits prolidase activity and its down-stream signaling proteins: HIF-1α, mTOR, AKT and MAPK p-38, while in the absence of estradiol, an opposite effect was observed. These results suggest that prolactin/estrogen cross-talk exert beneficial effect on prolidase-dependent down regulation of HIF-1α. It suggests that dual action of prolactin and estrogen may be considered as a strategy in therapy of breast cancer.

Keywords: Prolactin, estrogen, HIF-1 α, MCF-7, prolidase, cross-talk
Published online: 12-Apr-2013
Year: 2013, Volume: 60, Issue: 4 Page From: 355, Page To: 363

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