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Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.5, p.258-261, 2013
Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.5, p.258-261, 2013
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Bratislava Medical Journal Vol.114, No.5, p.258-261, 2013 |
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| Title: The role of calcium entry on the relaxation response of rho-kinase inhibitor in rabbit renal artery | ||
| Author: B. C. Soner, N. Murat, H. Guven, S. Gidener | ||
| Abstract: This study was performed to clarify the role of extracellular and intracellular Ca2+ on rho-kinase enzyme inhibition-induced relaxation in rabbit renal arteries. The response to rho-kinase inhibitor (Y-27632) was studied in isolated renal artery segments precontracted with phenylephrine in the presence of voltage-gated calcium channel blocker nifedipine and in the absence of intracellular or extracellular Ca2+. Cumulative addition of rho-kinase inhibitor Y-27632 (10-8–10-5 M) produced a concentration-dependent relaxation in renal artery rings precontracted with phenylephrine. Preincubation with nifedipine (1µM) resulted in a significant increase in relaxation response to rho-kinase inhibitor Y-27632 compared with preincubation with DMSO; the solvent of nifedipine. The maximal relaxation to Y-27632 in renal arteries precontracted with phenylephrine was significantly increased in the Ca-free Krebs containing 100 μmol/l ethylene glycol tetraacetic acid (EGTA) but after depletion of intracellular stores with 20 mmol/l caffeine and 1mmol/l EGTA in Ca2+ free Krebs there was no significant difference between the relaxation to Y-27632 from control response in 2.5 mmol/l Ca2+ Krebs in the renal artery. These results suggest the involvement of extracellular Ca and L-type voltage-operated Ca2+ channels in phenylephrine-induced rho-kinase activation (Fig. 3, Ref. 20). |
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| Keywords: rho-kinase, calcium, rabbit, renal artery. | ||
| Year: 2013, Volume: 114, Issue: 5 | Page From: 258, Page To: 261 | |
| doi:10.4149/BLL_2013_053 |
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