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Bratislava Medical Journal Vol.114, No.9, p.498--502, 2013 |
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Title: Analysis of expression of TNF-alpha and TGF-beta3 in intrinsic ureteropelvic junction obstruction | ||
Author: O. Koca, C. Kaya, M. I. Ozturk, M. Gunes, G. Gumrukcu, M. I. Karaman | ||
Abstract: bjectives: Ureteropelvic junction (UPJ) obstruction is of critical importance to understand the histopathology of UPJ obstruction in terms of therapy planning and follow-up. For this purpose, our study was conducted with TNF-α and TGF-β markers to investigate possible underlying problems in intrinsic UPJ obstruction. Results: The mean staining values for TNF-α in mucosal tissue and mucosa were 0.53±0.84 and 0.58±0.84, respectively in the obstruction group, whereas the values observed in the control group were 0.86±0.36 and 0.93±0.47, respectively. While the mean staining values in the obstruction group in mucosal tissue and mucosa for TGF-β3 were 1.75±0.73 and 2.17±0.77, respectively, the values established in the control group were 1.14±0.66 and 1.43±0.93, respectively. The difference between the obstruction and control groups were statistically significant for both values (p<0.05).
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Keywords: ureteropelvic junction obstruction, TGF-β3, TNF-α, cytokine. | ||
Year: 2013, Volume: 114, Issue: 9 | Page From: 498, Page To: 502 | |
doi:10.4149/BLL_2013_104 |
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