Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.10, p.566-568, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.114, No.10, p.566-568, 2013

Title: Prognostic significance of the preoperative serum levels of soluble form of endoglin in gastric cancer patients
Author: I. Gomceli, M. Tez, E. B. Bostanci, A. S. Kemik, B. Demiriz, M. Akoglu

Abstract:

Background: Gastric cancer is the second commonest cause of cancer-associated deaths in the world. Its molecular markers can be useful not only for the diagnostic pursuit but also for prognostic purposes. Endoglin was proposed as a marker of neovascularization in solid malignancies. A circulating form of endoglin is referred to as soluble endoglin (sol-end).The purpose of this study was to investigate the clinical importance of serum level of soluble form of sol-end in gastric cancer patients.
Materials and methods: Serum levels of sol-end were measured in 69 healthy controls and in 60 gastric adenocarcinoma patients with ELISA and serum levels of sol-end were compared with clinicopathological features and outcomes in gastric cancer patients.


Results: Serum levels of sol-end in gastric adenocancer patients were significantly higher than in control patients (p<0.001).

The serum levels of sol-end did not differ relative to clinical and pathologic criteria.
Conclusion: Presented data suggest that serum levels of sol-end do not seem to be a valuable tool in the assessment of gastric cancer prognosis (Tab. 1, Ref. 11).



Keywords: endoglin, gastric cancer, prognosis.
Year: 2013, Volume: 114, Issue: 10 Page From: 566, Page To: 568
doi:10.4149/BLL_2013_119


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