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Bratislava Medical Journal Vol.115, No.3, p.131-135, 2014 |
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Title: The effect of zoledronic acid on growth plates and high turnover bones | ||
Author: M. Erdogan, C. Bereket, N. Ozkan, O. Alici, I. Sener, E. E. Desteli, F. Ilkaya | ||
Abstract: Objectives: Bisphosphonates have preventive effect on bone resorption caused by osteoclasts. Methods: Thirty-six 12 week-old female Sprague-Dawley rats were divided into the control (C, n=18) and ZA groups (Z, n=18). Z group animals were administered 0.1 mg/kg saline-diluted ZA intraperitoneally three times per week for 8 weeks. C group animals were administered the same amount of saline simultaneously. At the end of 11th week, half the subjects from either the control group (C1) and ZA group (Z1) were sacrificed. At the end of 14th week, the remaining half from both groups were also sacrificed (C2 and Z2). In all animals, no dental procedures were performed; the posterior and anterior mandible and the knee joint including distal femur and proximal tibia were histopathologically investigated. |
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Keywords: inflammation, epiphysis, bisphosphonates. | ||
Year: 2014, Volume: 115, Issue: 3 | Page From: 131, Page To: 135 | |
doi:10.4149/BLL_2014_028 |
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