Home 
FOR AUTHORS Acta Virologica 2014 Acta Virologica Vol.58, No.1, p.69-75, 2014
FOR AUTHORS Acta Virologica 2014 Acta Virologica Vol.58, No.1, p.69-75, 2014
Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.58, No.1, p.69-75, 2014 |
||
| Title: Potential role of high-mobility group box 1 protein in the pathogenesis of influenza H5N1 virus infection | ||
| Author: X. Q. HOU, J. L. QIN, X. X. ZHENG, L. WANG, S. T. YANG, Y. W. GAO, X. Z. H. XIA | ||
| Abstract: During influenza A virus (IAV) (H5N1) infection, the levels of inflammatory cytokines are markedly elevated in the lungs of infected hosts. One of them, high-mobility group box 1 protein (HMGB1) functions in regulation of cellular transcription and activation of proinflammatory responses, but little is known about its role in viral infection. In this study, we attempted to address this question. Using an IAV (H5N1) – mouse model, lung tissues were analyzed for virus titer, expression of HMGB1 and other inflammatory cytokines and histopathological changes. Moreover, the effect of administration of HMGB1-specific antibody to the infected mice on these parameters was investigated. The results showed that the HMGB1 expression was induced on days 3–7 post infection (p.i.) and primarily localized to epithelial cells of alveoli and bronchioles. The HMGB1-specific antibody reduced the levels of inflammatory cytokines and chemokines and the survival rate, but did not influence the virus titer. Summing up, these data suggest that HMGB1 contributes to the pathogenesis of IAV (H5N1) infection in mice by inducing extensive inflammatory responses and severe pneumonia. |
||
| Keywords: HMGB1; influenza A virus (H5N1); pathogenesis | ||
| Year: 2014, Volume: 58, Issue: 1 | Page From: 69, Page To: 75 | |
| doi:10.4149/av_2014_01_69 |
||
|
|
 download file |
|