Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.5, p.272-274, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.115, No.5, p.272-274, 2014

Title: The effects of dexmedetomidine on pulmonary artery pressure in experiment
Author: Y. Unal, H. K. Pampal, M. Arslan, C. B. Demirel, M. Alkan

Abstract:

he primary purpose of this study is to assess the effects of dexmedetomidine (DEX) infusion on pulmonary artery pressures (PAP), heart rate (HR), and mean arterial pressure (MAP) in pigs. The secondary purpose is to evaluate whether DEX infusion via the pulmonary artery has any beneficial effect over the peripheral IV route.
Materials and methods: Sixteen healthy male pigs (25–35 kg) scheduled for laparoscopy training were used in this study. The animals were randomly allocated into two groups:

Group I (n = 9): A loading dose of 1µg/kg DEX was administered over 10 minutes followed by an infusion of 0.5 µg/kg/hr for one hour via the pulmonary artery catheter.

Group II (n = 7): A loading dose of 1 µg/kg DEX was administered over 10 minutes followed by an infusion of 0.5 µg/kg/hr for one hour via the peripheral venous catheter.

Mean PAP, HR, MAP, SpO2, and ETCO2 were recorded at 5, 10, 15, 30, 45, and 60 minutes after the initiation of the DEX infusion.



Keywords: pulmonary artery pressure, dexmedetomidine, pig.
Year: 2014, Volume: 115, Issue: 5 Page From: 272, Page To: 274
doi:10.4149/BLL_2014_056


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