Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.6, p.340-344, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.115, No.6, p.340-344, 2014

Title: In vitro motility changes in Roux limb after Roux-en-Y reconstructio
Author: N. Dogan, A. K. Gokakin, A. Koyuncu, I. Bagcivan, C. Aydin, O. Topcu, S. Yildirim

Abstract:

Background: The aim of this study is to compare the motility of Roux limb with that of normal segment.
Materials and methods: Rats were divided into 3 equal groups as control, Roux-en-Y (Group A) and Roux-en-Y with vagotomy (Group B). Only midline incision and manipulations were applied in control group. Following distal gastrectomy, Roux-en-Y reconstruction was applied in Group A, while vagotomy Roux-en-Y gastrojejunostomy was applied in Group B. Rats were sacrificed 1 month later by cervical dislocations under anesthesia. The obtained jejunal segments were cut into four equal parts. The bath was 37 °C warm while 95 % O2 and 5 % CO2 gases were supplied in 10 ml bicarbonate Krebs’ solution.
Results: KCl responses were similar in all three groups.

Acetylcholine contraction responses in the vagotomy and non-vagotomy Roux-en-Y groups was higher than in those in control group significantly (p < 0.05).

This response in vagotomy Roux-en-Y group was also higher than that in non-vagotomy group (p < 0.05).

The induced electrical field stimulation contraction response in the vagotomy + Roux-en-Y group was lower than those in control group and non-vagotomy group (p < 0.05).


Conclusions: These results show that muscarinic receptor density and/or function may increase after vagotomy and non-vagotomy group operation, and vagotomy may contribute to this increase. The decrease in electrical signal response in vagotomy Roux-en-Y group may depend on the decrease in acetylcholine oscillation from the cholinergic nerve ending (Tab. 1, Fig. 5, Ref. 25).



Keywords: Roux-en-Y, Roux stasis syndrome, acetylcholine, electrical field stimulation, jejunum, motility.
Year: 2014, Volume: 115, Issue: 6 Page From: 340, Page To: 344
doi:10.4149/BLL_2014_067


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