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Neoplasma Vol.61, No.5, p.579-584, 2014 |
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Title: Serum high mobility group box protein 1 as a clinical marker for ovarian cancer | ||
Author: Y. LI, J. TIAN, X. FU, Y. CHEN, W. ZHANG, H. YAO, Q. HAO | ||
Abstract: The aim of the study was to evaluate the clinical value of serum high mobility group box chromosomal protein 1 (HMGB1) in ovarian cancer and analyze the correlation between HMGB1 and ovarian cancer clinicopathologic outcomes. The mean value of serum HMGB1 levels in ovarian cancer patients (78.18±54.87ng/ml) was significantly higher than those in benign patients (33.98±9.97ng/ml) and healthy control (26.71±7.99ng/ml, p < 0.0001), respectively. The serum HMGB1 levels were 40.33±6.50ng/ml, 61.16±20.15ng/ml, 81.81±51.15ng/ml and 119.48±84.28ng/ml in patients with TNM stage I, II, III, and IV, respectively (p < 0.0001). There were 81 of the 105 ovarian cancer patients obtained complete remission, the serum HMGB1 levels before treatment(71.99±42.49ng/ml) were much higher than that at remission stage(42.10±15.48ng/ml) (p < 0.0001). During our investigating period, 28 ovarian cancer patients underwent recurrence, the serum HMGB1 levels were 75.54±39.50ng/ml in these recurrent ovarian cancer patients compared to 42.04±10.68ng/ml in non-recurrent ovarian cancer (p < 0.0001). None of the remission or recurrent patients came from benign ovarian tumor group. |
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Keywords: high mobility group box chromosomal protein 1, ovarian cancer, prognosis | ||
Published online: 16-Jul-2014 | ||
Year: 2014, Volume: 61, Issue: 5 | Page From: 579, Page To: 584 | |
doi:10.4149/neo_2014_070 |
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