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Bratislava Medical Journal Vol.115, No.9, p.538-543, 2014 |
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Title: Cardioprotective effect of aminoguanidine in combination with steroid therapy after blunt chest trauma | ||
Author: L. Duran, A. Guzel, H. U. Akdemir, F. Demir, C. Karadeniz, H. Alacam, A. Gacar, N. Murat, S. Ozdemir, T. Guvenc | ||
Abstract: Background: Cardiac contusion is an important cause of mortality after blunt chest trauma (BCT). The aim of this study was to investigate the therapeutic efficacy of the usage of aminoguanidine (AG), in myocardial damage occurring after BCT, alone and in combination with methylprednisolone (MP). Thirty-five female Wistar albino rats were randomly assigned to five groups (n = 7) including: sham controls (S); only cardiac contusion (CONT); cardiac contusion treated with methylprednisolone (CONT+MP); cardiac contusion treated with aminoguanidine (CONT+AG); and cardiac contusion treated with methylprednisolone and aminoguanidine (CONT+MP+AG). Seven days following the treatments, heart and serum specimens were evaluated histopathologically, immunohistochemically, and biochemically in all groups.
Increased iNOS expression in myocardial tissue was significantly decreased in the CONT+AG+MP group compared to CONT+AG and CONT+MP groups (p = 0.001 and p = 0.011, respectively). The combined treatment of AG and MP increased Bcl-2 expression significantly after contusions compared to the other treatment groups. |
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Keywords: cardiac contusion, blunt chest trauma, iNOS, Bcl-2, methylprednisolone, aminoguanidine. | ||
Year: 2014, Volume: 115, Issue: 9 | Page From: 538, Page To: 543 | |
doi:10.4149/BLL_2014_104 |
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