Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Bratislava Medical Journal Vol.115, No.9, p.563-568, 2014 |
||
Title: Frequencies of polymorphisms in CYP2C9 and VKORC1 genes influencing warfarin metabolism in Slovak population: implication for clinical practice | ||
Author: L. Krajciova, L. Deziova, R. Petrovic, J. Luha, P. Turcani, J. Chandoga | ||
Abstract: Objectives: The study was aimed at establishing an effective molecular-genetic method for detecting polymorphisms in genes CYP2C9 and VKORC1, which affect the pharmacogenetics of warfarin, and at determining their prevalence in Slovak population. In a control group of 112 randomly selected individuals, we tested the frequency of selected single nucleotide polymorphisms including CYP2C9*2 (430C>T), CYP2C9*3 (1075A>C), VKORC1*2 (1173C>T) by allele-specific Real-Time PCR and VKORC1*2 (-1639G>A) by using PCR-RFLP.
|
||
Keywords: warfarin, pharmacogenetics, CYP2C9, VKORC1, polymorphisms. | ||
Year: 2014, Volume: 115, Issue: 9 | Page From: 563, Page To: 568 | |
doi:10.4149/BLL_2014_109 |
||
|
download file |
|