Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.10, p.625-631, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.115, No.10, p.625-631, 2014

Title: Experimental research on end-to-side anastomosis of peripheral nerves and effect of FK506 on end-to-side anastomosis
Author: L. M. Yang, Y. X. Wu, X. P. Zhang, X. H. Li

Abstract: Objective: To study the effects of end-to-side anastomosis of initially-denatured nerves at different times.
Method: 60 male Wistar albino rats were used to fabricate animal models for the experiment on end-to-side anastomosis of peripheral nerves and 50 female Wistar albino rats were used to fabricate animal models for the experiment on the effect of FK506 on end-to-side anastomosis. Bilateral common peroneal nerve, tibialis anterior muscle electrophysiological and histological examinations, tibialis anterior muscle wet muscle weight determination, and motor end plate examination were performed 3 months after operation.
Results: All recovery rates of action potential, single muscle contraction force and tetanic contraction force of the FK506 experimental group are significantly higher than those of the control group and the sectional area of muscle fiber is also higher than that of the control group of normal saline.
Conclusion: The best time for end-to-side anastomosis of nerves should be controlled within 2 weeks and the effect of end-to-side anastomosis of nerves will gradually become unsatisfactory. FK506 plays a role in promoting functional rehabilitation following nerve end-to-side anastomosis (Tab. 7, Fig. 4, Ref. 31).

Keywords: peripheral nerves, end-to-side anastomosis, FK506, motor end plate, electrophysiological.
Year: 2014, Volume: 115, Issue: 10 Page From: 625, Page To: 631
doi:10.4149/BLL_2014_121


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