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Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.10, p.635-642, 2014
Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.10, p.635-642, 2014
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Bratislava Medical Journal Vol.115, No.10, p.635-642, 2014 |
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| Title: Correlations of ADHD symptoms with neurometabolites measured by 1H magnetic resonance spectroscopy | ||
| Author: V. Husarova, M. Bittsansky, I. Ondrejka, D. Dobrota | ||
| Abstract: Objectives: Despite the number of studies on neurometabolite changes in ADHD (Attention deficit/hyperactivity disorder), there is lack of evidence on neurometabolite associations with ADHD symptoms. Background: We aimed to find the correlations of neurometabolites with ADHD symptoms. Methods: Twenty ADHD children were examined by means of 1H-MRS. The spectra were taken from dorsolateral prefrontal cortex (DLPFC) and white matter behind DLPFC, bilaterally. Neurometabolites were correlated with ADHD-RS-IV (ADHD-Rating Scales IV), CPRS (Conners Parent rating Scale) and DPREMB (Daily Parent Rating of Evening and Morning Behavior) scores. Results: NAA/Cr (N-acetylaspartate/creatine) in the right DLPFC positively correlated with CPRS subscale IV learning problems and negatively correlated in the left white matter with DPREMB morning behavior subscale and ADHD-RS-IV score. Glx/Cr (glutamate + glutamine/creatine) positively correlated in the right white matter with ADHD-RS-IV and negatively correlated in the left white matter with DPREMB morning behavior subscale score. Cho/Cr (choline/creatine) in the left white matter negatively correlated with DPREMB morning behavior subscale and ADHD-RS-IV score. Conclusion: ADHD symptoms could result from different activities of the left- and right-hemisphere prefrontal circuits. In consequence to impulses to novel task searching the increased right prefrontal circuit activity could be mediated by different motivational control (Fig. 9, Ref. 73). |
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| Keywords: N-acetylaspartate, glutamate, choline, prefrontal cortex. | ||
| Year: 2014, Volume: 115, Issue: 10 | Page From: 635, Page To: 642 | |
| doi:10.4149/BLL_2014_123 |
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