Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.10, p.611-616, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.115, No.10, p.611-616, 2014

Title: Chemopreventive potential of alpha lipoic acid in the treatment of colon and cervix cancer cell lines
Author: I. Damnjanovic, G. Kocic, S. Najman, S. Stojanovic, D. Stojanovic, A. Veljkovic, I. Conic, T. Langerholc, S. Pesic

Abstract: Objectives: The nuclear factor κB regulates the expression of genes involved in many processes that play a key role in the development and progression of cancer. The aim of this study was to examine the influence of the alpha lipoic acid in the chemoprevention of colon and cervix carcinoma in vitro.
Background: In recent years, special attention has been paid to the potential chemopreventive properties of antioxidants. There are no published data on the impact of alpha lipoc acid of chemoprevention of cervix and colon cancer.
Methods: We examined the effect of alpha lipoic acid alone or in combination with cisplatin and 5-fluorouracil on proliferation of the two cell lines, HeLa (human cervical carcinoma cells) and Caco-2 (human colon cancer cells) by MTT test. The measurement of the level of transcription factor NF-κB was also performed in the cells of both cell lines.
Results: At least one of the mechanisms of the antiproliferative and/or cytotoxic effect of alpha lipoic acid on Caco-2 and HeLa cells at high concentrations, the transcription factor NF-κB, may be involved, as well as the products of transcription of genes that are under its control.
Conclusion: The alpha lipoic acid has proven to be a promising candidate in the combat arena against cancer (Tab. 4, Ref. 31).

Keywords: alpha lipoic acid, chemoprevention, HeLa cells, Caco-2 cells, nuclear factor κB
Year: 2014, Volume: 115, Issue: 10 Page From: 611, Page To: 616
doi:10.4149/BLL_2014_118


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