Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.11, p.680-684, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.115, No.11, p.680-684, 2014

Title: The protective effects of dexmedetomidine on hepatic ischemia reperfusion injury
Author: A. Kucuk, F. Yaylak, A. Cavunt-Bayraktar, M. Tosun, M. Arslan, F. M. Comu, M. Kavutcu

Abstract:

Objective: The aim of this study was to evaluate the effect of dexmedetomidine (100 µg/kg-ip) on liver ischemia and reperfusion (I/R) in rats.
Methods: Twenty-four Wistar Albino rats were separated into three groups as control (C), ischemia-reperfusion injury (I/R) and dexmedetomidine group (I/R-D). Ischemia was induced with portal clampage for 45 minutes and reperfusion period was 45 minutes after declampage. Group I/R-D was received dexmedetomidine 100 µg/kg i.p. 30 min before portal clampage. Thiobarbutiric Acid-Reactive Substances (TBARS), glutathioneS-transferase (GST), superoxide dismutase (SOD), Catalase (CAT), and Paraoxonase 1 (PON-1) were investigated in blood samples. Also HSP60 and p53-positive hepatocytes were counted under ImageJ image analysis program.

Results:

All parameters, except GST levels, were significant between the groups (p < 0.05).

Although HSP60 expression was significantly increased between I/R, I/R-D and C groups there were no significant differences between I/R-D and C (p = 0.443).

On the other hand, p53 expression was also significantly increased between I/R, I/R-D and C groups

At the same time, there were no significant differences between I/R-D and C groups (p = 0.354).


Conclusion: All the results suggest that dexmedetomidine has beneficial effects on liver ischemia/reperfusion stress (Tab. 1, Fig. 2, Ref. 49).



Keywords: dexmedetomidine, ischemia reperfusion, HSP60, p53, rat.
Year: 2014, Volume: 115, Issue: 11 Page From: 680, Page To: 684
doi:10.4149/BLL_2014_132


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