Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.11, p.699-703, 2014

Journal info


 


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.115, No.11, p.699-703, 2014

Title: Caffeine alters oxidative homeostasis in the body of BALB/c mice
Author: M. Pohanka

Abstract: Caffeine is a metabolite from coffee genus and some other plants. It has disparate molecular targets in the body. Beside the major action based on antagonism on adenosine receptor, it is involved in other neurotransmission pathways as well. The complete mechanism of caffeine action remains unrevealed including link to oxidative homeostasis. For the reason, the current paper solves how caffeine influences oxidative homeostasis in BALB/c mouse model. Caffeine was given intramuscularly in doses 1–64 mg/kg and the animals were sacrificed in time intervals from 4 hours up to 3 days. In the experiment, a significant increase of thiobarbituric acid reactive substances (TBARS) levels in the kidney and decrease in the brain indicated up and down regulation of oxidative burden. Ferric reducing antioxidant power (FRAP) level in the kidney appoint at release of low molecular weight antioxidants in the organ. The remaining organs including heart, muscles and liver were intact. In the same way, caspase 3 level was steady and no apoptotic processes were proved (Fig. 3, Ref. 48).

Keywords: caffeine, oxidative stress, antioxidant, adenosine receptor, Alzheimer disease, neurodegeneration.
Year: 2014, Volume: 115, Issue: 11 Page From: 699, Page To: 703
doi:10.4149/BLL_2014_135


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.