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Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.12, p.753-756, 2014
Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.12, p.753-756, 2014
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Bratislava Medical Journal Vol.115, No.12, p.753-756, 2014 |
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| Title: Role of the nitric oxide on rosuvastatin-induced relaxation of the calf cardiac vein during cooling | ||
| Author: M. S. Guresir, K. E. Nurullahoglu Atalik | ||
| Abstract: Objective: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors including rosuvastatin do not only lower plasma cholesterol but also have non-cholesterol lowering effects on the vessel wall, which decrease cardiovascular complications. The aim of the present study was to evaluate the effect of cooling (to 28 °C) on the vasodilatation induced by rosuvastatin (10-9-3x10-4M) on serotonin-pre-contracted calf cardiac vein and the role of nitric oxide in these effects. Material and methods: Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 25 ml of Krebs-Henseleit solution, maintained at 37 °C and continuously gassed with 95% O2–5% CO2. After a resting period, preparations were contracted with serotonin (10-6 M) at 37 °C. Results: Rosuvastatin produced concentration-dependent relaxation of calf cardiac vein precontracted with serotonin (10-6 M). During cooling, the pIC50 value, but not the maximal response, to rosuvastatin was significantly higher than at 37 °C. Cooling to 28 °C in the presence of NG-nitro-L-arginine methyl ester (L-NAME, 10-4 M) decreased the pIC50 values to rosuvastatin. Conclusion: The results of the present study suggested that nitric oxide played an essential role in the cooling-induced changes of rosuvastatin in calf cardiac vein (Fig. 1, Ref. 23). |
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| Keywords: cardiac vein, cooling, nitric oxide, rosuvastatin. | ||
| Year: 2014, Volume: 115, Issue: 12 | Page From: 753, Page To: 756 | |
| doi:10.4149/BLL_2014_145 |
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