Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.3, p.150-153, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.116, No.3, p.150-153, 2019

Title: Influence of Rho kinase inhibitor fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension
Author: P. Liu, H. M. Zhang, Y. J. Tang, C. F. Sheng, J. X. Liu, Y. J. Zeng
Abstract: Objective: To investigate the influence of Fasudil, a Rho inhibitor on the number and functions of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension.
Background: It is not clear yet, whether Rho Kinase Inhibitor Fasudil can reduced pulmonary artery pressure through improving lung endothelial function.
Methods: 80 COPD patients with pulmonary artery hypertension were selected and divided into two groups: the treatment group and the control group, which had 40 patients, respectively. Changes in the number and function of the late endothelial progenitor cells in peripheral blood of the patients before and after the treatment were compared between the two groups. The changes on the pulmonary artery pressure were also compared.
Results: The number of the late endothelial progenitor cells in peripheral blood of the treatment group increased and the function was enhanced. The pulmonary artery pressure was reduced. The difference before and after the treatment and with the control group was statistically significant (p < 0.05).
Conclusions: The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension (Tab. 3, Fig. 2, Ref. 17).
Keywords: Rho kinase inhibitor Fasudil, chronic obstructive pulmonary diseases, pulmonary artery hypertension, endothelial progenitor cells.
Year: 2015, Volume: 116, Issue: 3 Page From: 150, Page To: 153
doi:10.4149/BLL_2015_030


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