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Bratislava Medical Journal Vol.116, No.3, p.177-183, 2015 |
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Title: Ameliorative effect of Leflunomide on lung injury following an aspiration | ||
Author: M. Z. Yilmaz, A. C. Torun, A. Guzel, N. Murat, A. Okuyucu, N. Yilmaz, A. Gacar, T. Guvenc, A. Guzel | ||
Abstract: Background: We aimed to investigate the therapeutic effectiveness of leflunomide (LEF) in lung injury after an aspiration of unknown pathophysiology. There was a significant increase in serum levels of YKL-40, a chitinase-like protein, in the HCl group after the aspiration (p<0.01). The increase in serum YKL-40 levels decreased significantly with LEF treatment (p<0.01). There was no significant difference in serum YKL-40 levels in the FOR group compared to the control group at pretreatment and in the FOR+LEF group at post-treatment. There was a significant increase in serum thiobarbituric acid-reactive species (TBARS) values in the HCl and FOR groups compared to the control group (p=0.001 and p<0.01, respectively). In both treatment groups, the serum TBARS values significantly decreased after treatment with LEF (p=0.001 and p<0.05, respectively). There was a significant improvement in the histopathological scores, which deteriorated after the aspiration, and in the number of inducible nitric oxide synthase (iNOS)-positive cells after treatment with LEF. |
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Keywords: aspiration, lung injury, Leflunomide, iNOS, oxidative markers. | ||
Year: 2015, Volume: 116, Issue: 3 | Page From: 177, Page To: 183 | |
doi:10.4149/BLL_2015_036 |
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