Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.4, p.241-247, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.116, No.4, p.241-247, 2015

Title: The histopathological effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion
Author: G. L. Oktar, N. Demir Amac, C. Elmas, M. Arslan, G. Goktas, E. Iriz, D. Erer, M. H. Zor, T. Tatar

Abstract:

Background: The aim of this study was to evaluate the histological and immunohistochemical effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion (I/R) in a rat model.


Methods: Twenty-four male Wistar Albino rats were randomly divided into the four groups: Group C (Control, n = 6), Group I/R (n = 6), Group BI (I/R group treated with levosimendan before ischemia, n = 6), and Group AI (I/R group treated with levosimendan after ischemia, n = 6).

Myocardial I/R was induced by ligation of the left anterior descending coronary artery for 30 min followed by two hours of reperfusion in I/R and I/R+Levosimendan groups. At the end of the study, liver tissue samples were obtained for histopathological and immunohistochemical examination.
Results: Masson Trichrome staining revealed significant hepatocyte degeneration and necrosis most marked in portal acinus Zone 3, especially around the central veins in Group I/R. Histopathological changes in Group AI were more similar to the changes in Group I/R. Milder hepatocellular degeneration was found in Group BI, when compared to groups I/R and AI.

Immunohistochemical score was found to be significantly higher in Group I/R compared to groups C, BI and AI (p < 0.0001).

The scores in groups BI and AI were found to be similar (p = 0.068).


Conclusion: Levosimendan ameliorates liver injury induced by myocardial IR, especially when administered before induction of ischemia (Fig. 9, Ref. 37).



Keywords: levosimendan, myocardial ischemia reperfusion, remote organ, liver injury, i-NOS, rat.
Year: 2015, Volume: 116, Issue: 4 Page From: 241, Page To: 247
doi:10.4149/BLL_2015_047


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