Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.4, p.252-258, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.116, No.4, p.252-258, 2015

Title: The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues
Author: E. Altinoz, Y. Turkoz, N. Vardi

Abstract:

The aim of this study was to investigate the protective effects of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues in rats.
The rats were divided into four groups.

Acrylamide administration increased MDA levels in all tissues significantly (p < 0.05).

But acrylamide+NAC administration decreased MDA levels significantly as compared to the acrylamide group, and lowered it to a level close to the control group values (p < 0.05).

GSH levels in liver and small intestine tissues reduced significantly in the acrylamide group (p < 0.05).

But acrylamide+NAC administration increased GSH levels significantly in all tissues.

Whereas GST activity decreased significantly in the acrylamide group in liver and small intestine tissues as compared to the other groups (p < 0.05), the GST activity increased significantly in the acrylamide+NAC group in all tissues as compared to the acrylamide group (p < 0.05).

Liver histopathology showed that the liver epithelial cells were damaged significantly in the acrylamide group. Small intestine histopathology showed that the intestinal villous epithelial cells were damaged significantly in the acrylamide group.
Our results indicate that a high level of acrylamide causes oxidative damage in liver and small and large intestine tissues, while N-acetylcysteine administration in a pharmacological dose shows to have an antioxidant effect in preventing this damage (Tab. 2, Fig. 2, Ref. 66).



Keywords: acrylamide, N-acetylcysteine, oxidative stress, liver, small and large intestine.
Year: 2015, Volume: 116, Issue: 4 Page From: 252, Page To: 258
doi:10.4149/BLL_2015_049


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