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Neoplasma Vol.62, No.3, p.391-397, 2015 |
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Title: 17-AAG enhances the cytotoxicity of flavopiridol in mantle cell lymphoma via autophagy suppression | ||
Author: Y. XIAO, J. GUAN | ||
Abstract: Flavopiridol, a cyclin-dependent kinase inhibitor (CDKI), shows promising anti-tumor activity in hematologic malignancies. However, Flavopiridol-induced protective autophagy may lead to drug resistance. Here we found that Hsp90 inhibitor 17-AAG can sensitize mantle cell lymphoma (MCL) cells to flavopiridol by suppressing flavopiridol-triggered protective autophagy. The suppressing effect of 17-AAG on autophgy was mediated by Beclin1 degradation and ERK inactivation. Furthermore, 17-AAG enhanced flavopiridol-induced apoptosis and growth suppression in MCL cells. Our study may provide some insights into CDKI -targeted chemotherapies. |
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Keywords: flavopiridol, 17-AAG, MCL, autophagy | ||
Published online: 01-Apr-2015 | ||
Year: 2015, Volume: 62, Issue: 3 | Page From: 391, Page To: 397 | |
doi:10.4149/neo_2015_047 |
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