Home Neoplasma 2015 Neoplasma Vol.62, No.4, p.641-645, 2015

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Neoplasma Vol.62, No.4, p.641-645, 2015

Title: Association between computed tomography-detected calcification and thyroid carcinoma
Author: W. LIU, X. DONG, C. ZHU, J. YANG, J. YANG, K. SHAO, L. YUAN, H. CHEN, W. LU, Y. ZHU

Abstract:

This study aimed to investigate the diagnostic value of calcification detected by computed tomography (CT) for the differentiation of benign and malignant thyroid nodules. This is a retrospective study of 930 consecutive patients (709 women, 221 men; mean age 51 years) with pathologically proven thyroid nodules. The characteristics of calcification on CT images were correlated with the pathological results. A total of 168 patients were pathologically diagnosed with thyroid carcinomas and 762 patients with benign thyroid nodules. Calcification was found in 231 cases (24.84%).

The incidence of calcification was significantly higher in patients with thyroid carcinoma (52.38%) than in those with benign nodules (18.77%; P < 0.001).

Detection of calcification in diagnosing thyroid carcinoma had a sensitivity of 52.38% (88/168) and specificity of 81.23% (619/762).

No significant difference was noticed in the incidence of microcalcification (≤ 2 mm) between malignant and benign nodules (P = 0.305).

Calcification is more frequently found in thyroid carcinomas than benign nodules. CT detected-calcification may suggest malignant disease. Further confirmation of the suspected malignancy with fine-needle aspiration or surgery is still needed.



Keywords: thyroid neoplasm, thyroid nodule, calcinosis, computed tomography
Published online: 18-May-2015
Year: 2015, Volume: 62, Issue: 4 Page From: 641, Page To: 645
doi:10.4149/neo_2015_077


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