Home Neoplasma 2015 Neoplasma Vol.62, No.4, p.674-682, 2015

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ISSN 1338-4317 (online)

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Neoplasma Vol.62, No.4, p.674-682, 2015

Title: Acute toxicity of robotic ultrahypofractionated radiotherapy CyberKnifeTM in prostate cancer patients
Author: G. GLOWACKI, W. MAJEWSKI, P. WOJCIESZEK, K. GRABINSKA, E. CHAWINSKA, D. BODUSZ, G. WOZNIAK, H. URBANCZYK, A. KALETKA, L. MISZCZYK

Abstract: Our purpose was to evaluate the toxicity of CyberKnifeTM based fractionated stereotactic radiotherapy (FSRT) in prostate cancer patients. One-hunred-thirty-two men with low (62) and intermediate (70) prostate cancer were enrolled in our prospective study. Mean age was 69. Total dose of 36,25 Gy in 5 fractions was prescribed. Image guided FSRT was performed on CyberKnife. Minimum follow-up ranged from 3 to 28 months. EORTC/RTOG scale was used to evaluate toxicity. A total of 47%, 10% and 2% of patients presented grade 1, 2 and 3 acute genitourinary toxicity, respectively. In 25% and 3% of patients, respectively, grade 1 and 2 acute gastrointestinal toxicity was observed. No significant association between acute grade ≥ 2 toxicity and clinical factors: age, androgen deprivation therapy or infections were found. Neither CTV nor PTV volumes had significant impact on acute grade ≥ 2 toxicity. Late toxicity was assessed in 104 patients. In 16% and 1% of patients late GU toxicity in grade 1 and 2, respectively, was presented. Late GI toxicity grade 1, 2 and 3 occurred in 8%, 3% and 1% of patients, respectively. The acute toxicity rates of fractionated stereotactic radiotherapy are low. Early data suggest also low late toxicity rates.

Keywords: CyberKnife, prostate cancer, toxicity, radiotherapy
Published online: 01-Jul-2015
Year: 2015, Volume: 62, Issue: 4 Page From: 674, Page To: 682
doi:10.4149/neo_2015_081


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