Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.9, p.547–553, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.116, No.9, p.547–553, 2015

Title: Petroselinum crispum extract attenuates hepatic steatosis in rats fed with fructose enriched diet
Author: V. Yuneesha Nair, N. Balakrishanan, J. Victor Antony Santiago

Abstract: Non alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and ongoing research efforts are focused on understanding the underlying pathophysiology of hepatic steatosis with the anticipation that these efforts will identify novel therapeutic targets. This study investigated the Petroselinum crispum extract in hepatic steatosis in rats fed with fructose enriched diet. Rats were divided into the 4 groups: Group 1 rats received standard pellet diet with corn starch for the entire experimental period of 8 weeks. Group 2 rats received standard pellet diet and 2 gm/kg body weight crude Parsley leaf ethanol extract for the entire experimental period of 8 weeks. Group 3 rats received modified fructose diet. Group 4 rats received modified fructose diet and 2gm/kg crude Parsley leaf ethanol extract. Hepatic function and structure was evaluated in these rats. Modified fructose diet produced dyslipidemia, hepatic steatosis and infiltration of inflammatory cells in the liver and higher plasma hepatic markers. Petroselinum crispum extract reversed metabolic changes such as abnormal hepatic function tests and liver pathology. These results suggested that a non-nutritive role for Petroselinum crispum extract attenuated chronic changes in modified fructose diet induced NAFLD (Tab. 2, Fig. 3, Ref. 43). Text in PDF www.elis.sk.

Keywords: Petroselinum crispum, non alcoholic fatty liver disease, non alcoholic steatohepatitis, lipid-hepatic function indicator.
Published online: 17-Sep-2015
Year: 2015, Volume: 116, Issue: 9 Page From: 547, Page To: 553
doi:10.4149/BLL_2015_107


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