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Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.10, p.580–581, 2015
Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.10, p.580–581, 2015
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Bratislava Medical Journal Vol.116, No.10, p.580–581, 2015 |
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| Title: Novel potential for the management of Alzheimer disease | ||
| Author: E. Ginter, V. Simko, D. Weinrebova, Z. Ladecka | ||
| Abstract: Pathologic characteristics of Alzheimer disease (AD) are β-amyloid (Aβ) plaques, neurofibrillary tangles (NFT) and neurodegeneration. Currently, there is no cure for AD. Cilostazol, a selective inhibitor of type 3 phosphodiesterase, is likely to be a promising agent for AD. In the brain of the experimental animals it significantly reduced the Aβ amyloid plaques. Initial clinical reports on the effect of Cilostazol in AD patients are promising. In mice, stem cells favourably influence the pathogenetic process critical in AD, by reducing deposits of Aβ plaques. Clinical trials of the drug, called Betablock, are already underway in Britain. Successful management and resolution of AD in man will still require further intensive research (Fig. 4, Ref. 11). |
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| Keywords: Alzheimer disease, β-amyloid plaques, Cilostazol, stem cells. | ||
| Published online: 28-Oct-2015 | ||
| Year: 2015, Volume: 116, Issue: 10 | Page From: 580, Page To: 581 | |
| doi:10.4149/BLL_2015_112 |
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