Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.1, p.15-18, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.116, No.1, p.15-18, 2016

Title: Soluble receptor for advanced glycation end products in late-onset neonatal infection
Author: B. Zolakova, V. Zolak, J. Hatok, K. Matasova, S. Nosal, M. Zibolen

Abstract: OBJECTIVES: To assess the plasma levels of sRAGE (soluble receptor for advanced glycation end products) in infected and non-infected preterm neonates and to compare their diagnostic values with standard infection biomarkers.
BACKGROUND: RAGE activates pathways responsible for acute and chronic inflammation. The soluble type of this receptor, sRAGE, which acts as a decoy receptor, has been linked to the severity of sepsis and its outcome.
METHODS: Prospective clinical study was carried out from January 2011 to August 2013. There were 33 neonates included according to their infection status and divided into subgroups as follows: infected (I), septic (S), non-infected controls (C).
RESULTS: We found significantly lower values of sRAGE in the subgroup S (905.54±220.53 pg/mL; p < 0.028), while borderline values were higher in the subgroup I vs C (2158.33±197.33 pg/mL vs 1744.80±157.74 pg/mL; p < 0.064). By analysing the interobserver concordance we detected 70 % agreement as to sRAGE values detected in neonatal late-onset infections and sepsis, while procalcitonin was used as golden standard.
CONCLUSION: Plasma sRAGE values reflect the severity of the inflammatory status in late-onset infection and sepsis in preterm neonates. Our results indicate that sRAGE could be a good potential biomarker of late-onset neonatal infection and sepsis (Tab. 2, Ref. 14).

Keywords: sRAGE, biomarker, preterm neonate, late-onset infection, late-onset sepsis
Published online: 21-Jan-2016
Year: 2016, Volume: 116, Issue: 1 Page From: 15, Page To: 18
doi:10.4149/BLL_2016_003


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