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Bratislava Medical Journal Vol.116, No.1, p.47-53, 2016 |
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Title: Combination effect of melatonin and dexamethasone on liver ischemia/reperfusion injury | ||
Author: M. Taghizadieh, B. Hajipour, N. Ahmadi Asl, A. Khodadadi, M. H. Somi, M. Banei | ||
Abstract: OBJECTIVE: Liver failure following ischemia-reperfusion (I/R) injury is a major concern in liver surgery. The purpose of this study was to evaluate combination pretreatment with melatonin (MEL) and dexamethasone (DEX) on liver I/R model. Male Wistar rats (n = 60) were assigned to 5 groups of 12 animals each: (1) Sham: laparotomy without I/R; (2) I/R: hepatic I/R; (3) I/R+MEL: hepatic I/R+melatonin injected intraperitoneally (20 mg/kg); (4) I/R+DEX: hepatic I/R+ dexamethasone injected intravenously (10 mg/kg); (5) I/R+MEL+DEX: hepatic I/R+ melatonin injected intraperitoneally+dexamethasone injected intravenously. The liver was subjected to ischemia by clamping the portal triad for 30 minutes and then reperfused for 6 hours after ischemia by removing the clamps.
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Keywords: liver, ischemia/reperfusion, melatonin, dexamethasone, rat | ||
Published online: 21-Jan-2016 | ||
Year: 2016, Volume: 116, Issue: 1 | Page From: 47, Page To: 53 | |
doi:10.4149/BLL_2016_010 |
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