Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.2, p.77-79, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.116, No.2, p.77-79, 2016

Title: Lack of serum antineuronal antibodies in children with autism
Author: A. K. Bayram, F. Kardas, E. O. Demirci, S. Gokahmetoglu, S. Ozmen, M. Canpolat, D. B. Oztop, S. Kumandas, H. Gumus, H. Per

Abstract: OBJECTIVE: Autism spectrum disorders (ASDs) are a severe group of neurodevelopmental disorders that are characterized by impairment in social communication, and imagination and social interaction. The aetiology of autism is complex, but some studies suggest autoimmunity to the central nervous system in the pathogenesis. The aim of this study is to investigate the positivity of antineuronal antibodies including anti-glutamic acid decarboxylase antibodies (anti-GAD), anti-glutamate receptor (anti-GluR) antibodies and seven types of anti-ganglioside antibodies, in children with autism.
METHODS: We conducted the study over a period of one year from May 2012 to December 2013. Human anti-GAD in serum were investigated with ELISA; human autoantibodies against the N-methyl-D-aspartate subtype of GluR were investigated with indirect immunofluorescence test; class IgG antibodies against the seven gangliosides were investigated with immunoblot assay.
RESULTS: Serum antineuronal antibodies were measured in 42 children (24 male, 18 female) with autism in comparison to 21 (13 male, 8 female) healthy-matched children aged between 2-12 years. There was no seropositivity of antineuronal antibodies in either of the groups.
CONCLUSION: There is no evidence to support an association between autism and antibodies positivity of anti-GAD, anti-GluR and anti-gangliosides (Ref. 26).

Keywords: Autism, antineuronal antibodies, glutamic acid decarboxylase, glutamate receptor, ganglioside antibodies, autoimmunity
Published online: 24-Jan-2016
Year: 2016, Volume: 116, Issue: 2 Page From: 77, Page To: 79
doi:10.4149/BLL_2016_015


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