Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.5, p.295-298, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.117, No.5, p.295-298, 2016

Title: Investigation of histopathological effects after intra-arterial sugammadex injection in an experimental animal model
Author: H. A. Kiraz, H. Toman, M. Erbas, Y. Yuyucu Karabulut, T. Simsek, V. Hanci, M. Uzun

Abstract: PURPOSE: Intra-arterial injection of medications are related to mortality and morbidity. It was aimed to investigate the histopathological effects caused by two different intra-arterial doses of sugammadex, a new selective relaxant binding agent used to reverse the effects of steroidal systemic muscle relaxants used in surgeries carried out under general anesthesia.
METHODS: A total of 15 rabbits were randomly divided into 3 groups. The control group was given 1 mL saline bolus into the central artery of the ear. The other two groups (Group Sgdx2 and group Sgdx16) were given 2 and 16 mg/kg sugammadex, respectively, intra-arterially.
RESULTS: In control group, histopathological evaluation was in normal limits. The cross-sections belonging to Group Sgdx2 did not have any significant pathological change compared with control group (p > 0.05). Edema and single-cell necrosis were significantly higher in Group Sgdx16 when compared to control group (p < 0.05). In comparison to Group Sgdx2, single-cell necrosis was significantly higher in Group Sgdx16 (p < 0.05).
CONCLUSION: Being broadly used in anesthesia, sugammadex should be administered with care because when given by intra-arterial route it may cause tissue damage and tissue loss and the patients’ arteries should be carefully checked (Tab. 2, Fig. 3, Ref. 21).

Keywords: dose, experimental, intra-arterial, rabbit, sugammadex
Published online: 13-May-2016
Year: 2016, Volume: 117, Issue: 5 Page From: 295, Page To: 298
doi:10.4149/BLL_2016_058


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