Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.6, p.308-311, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.117, No.6, p.308-311, 2016

Title: Dominant neurologic symptomatology in intravascular large B-cell lymphoma
Author: K. Kubisova, P. Martanovic, V. Sisovsky, Z. Tomleinova, A. Steno, P. Janega, B. Rychly, P. Babal

Abstract: Intravascular large B-cell lymphoma (IVLBCL) is a rare variant of extranodal large B-cell lymphoma and it is characterized by selective intravascular proliferation of malignant cells. Typical features of the disease include aggressive behavior, rapid and frequently fatal course. Clinical picture is non-specific and heterogeneous, depending on the affected organ. It is not uncommon that this unique type of lymphoma is diagnosed post mortem. Herein, we report two cases of IVLBCL with neurologic symptomatology. In our clinical study patient 1 was an 80-year-old male with mixed paraparesis of lower extremities and difficulties with sphincter control. Patient 2 (56-year-old male) had vision malfunction, mental status changes and defect in phatic and motor functions. In both cases definite diagnosis was established by histological examination of necroptic material. We propose to include IVLBCL in differential diagnostic considerations in patients presenting with gradually impairing neurological status and spinal cord damage of unknown etiology (Fig. 2, Ref. 9).

Keywords: intravascular large B-cell lymphoma, CNS vessels, neurologic symptoms
Published online: 13-Jun-2016
Year: 2016, Volume: 117, Issue: 6 Page From: 308, Page To: 311
doi:10.4149/BLL_2016_061


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