Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.6, p.316-320, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.117, No.6, p.316-320, 2016

Title: Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in patients with restless legs syndrome
Author: G. Halac, E. Kilic, M. A. Cikrikcioglu, K. Celik, A. Toprak-Erek, S. Keskin, I. Gultepe, R. S. Celik, N. Ozaras, A. Yildiz, S. Aydin, O. Akan, C. Karatoprak, Y. Sekin, T. Asil

Abstract: OBJECTIVE: The aim of this study was to assess the predisposition for atherosclerosis in patients with RLS through serum sLOX-1 (serum Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) measurements.
BACKGROUND: Recent epidemiological studies have suggested an association of RLS with certain chronic conditions such as diabetes mellitus (DM), obesity, hypertension (HT), and hyperlipidemia. LOX-1 is expressed in endothelial cells, macrophages, and in smooth muscle cells under the effect of proatherogenic conditions.
METHODS: This study was a prospective, cross-sectional, case-controlled. We measured the serum sLOX-1 levels in 37 restless legs syndrome patients and 38 controls.
RESULTS: Serum sLOX-1 level was significantly lower in the patient group. The two groups were similar in glucose, HbA1c, creatinine, LDL cholesterol, TG, HDL, total protein, albumin, AST, ALT, GGT, ALP, HGB, HCT, MCV, transferrin saturation rate (TSR), ferritin, CRP, TSH, FT4, FT3, B12, and folic acid levels. Also the two groups were similar with respect to age at menarche, number of previous births, number of abortions and/or curettage, total duration of breastfeeding, percentage of patients in menopause, and age at menopause.
CONCLUSION: Our results may suggest a lower atherosclerotic risk among RLS patients as compared to the general population (Tab. 3, Ref. 33).

Keywords: restless legs syndrome, atherosclerosis, sLOX-1
Published online: 13-Jun-2016
Year: 2016, Volume: 117, Issue: 6 Page From: 316, Page To: 320
doi:10.4149/BLL_2016_063


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