Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.8, p.448-452, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.117, No.8, p.448-452, 2016

Title: Vertebrobasilar insufficiency and gamma-glutamyltransferase: An emerging relationship demonstrating inflammation and atherosclerosis
Author: M. S. Ulu, M. Beker-Acay, S. Ulu, E. Unlu, A. Bucak, G. Yaman, A. Altug, M. S. Tekin, S. Oruc

Abstract:

OBJECTIVES: Vertebrobasilar insufficiency (VBI) is a pathology arising from the reduction in flow rate of vertebral arteries and mainly caused by inflammation and atherosclerosis. Gamma-glutamyltransferase (GGT) is a marker which has been recently recognized as a marker of inflammation and atherosclerosis. We aimed to investigate the relationship between GGT levels and VBI for the first time.
METHODS: In this cross-sectional study, of 3100 subjects who had vertebrobasilar doppler ultrasonography (VBU) were evaluated and 1042 of them who met the inclusion criterias were included. VBU reports, GGT levels, blood chemistry, lipid profile were received from patients’ files. Patients were evaluated according to VBU measurements and divided into two groups,VBI and non-VBI.
RESULTS: Mean vertebral arterial blood flow volume values were 149.99±32.93 mL/m in VBI group and 286.88 ± 70.98 mL/m in non-VBI group. Mean GGT and CRP values were significantly higher in the VBI group than in the non-VBY group (p < 0.001) ( p < 0.001), respectively.

Vertebral artery blood flow volume was negatively correlated with GGT (r: –0.208, p < 0.001) and CRP (r: –0.119, p < 0.001).
CONCLUSION: We demonstrated a significant correlation between serum GGT levels and VBI. In addition, higher GGT level was an independent risk factor for the presence of vertebrobasilar system inflammation and atherosclerosis (Tab. 2, Fig. 3, Ref. 27).



Keywords: vertebrobasilar insufficiency, inflammation, atherosclerosis, gamma-glutamyltransferase
Published online: 10-Aug-2016
Year: 2016, Volume: 117, Issue: 8 Page From: 448, Page To: 452
doi:10.4149/BLL_2016_087


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