Bratislava Medical Journal Vol.117, No.8, p.472-479, 2016
|
Title: Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis-related genes in diabetic rats |
Author: M. Alipour, B. Amini, F. Adineh, H. Feizi, M. R. Jafari |
|
Abstract: Memory impairment is a common disorder in diabetes mellitus which is associated with hippocampal neuronal apoptosis. The present study was conducted to examine the effect of one-week intraperitoneal (ip), administration of aminoguanidine (AG) on passive avoidance learning (PAL) and Bcl-2 family gene expression in the hippocampus of rats. Sixty male rats were divided into ten groups: non-diabetic/diabetic animals with/without AG (50, 100, 200 and 400 mg/kg, ip) treatment for one week. PAL and Bcl-2 family genes were examined. AG (100 and 200 mg/kg) improved both memory and Bax, Bak, Bcl–2 and Bcl-xl deficiency significantly in diabetic rats. AG treatment also ameliorated the diabetes-induced changes in (Bcl–2+Bcl-xl)/(Bak+Bax) ratios considerably. These results propose that one-week ip administration of AG may recover the deficit cognition in diabetic rats via enhancing (Bcl–2+Bcl-xl)/(Bak+Bax) proportions (Tab. 2, Fig. 4, Ref. 55).
|
|
Keywords: rats, diabetes mellitus, aminoguanidine, passive avoidance learning, Bcl-2 family genes |
|
Published online: 10-Aug-2016
|
Year: 2016, Volume: 117, Issue: 8 |
Page From: 472, Page To: 479 |
doi:10.4149/BLL_2016_092
|
|
download file |
|
|
|
|