Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.8, p.480-485, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.117, No.8, p.480-485, 2016

Title: Prolidase
Author: E. S. Namiduru

Abstract: Prolidase (EC.3.4.13.9) or proline dipeptidase, is one of the unique enzyme capable of degrading dipeptides, in which a proline or hydroxyproline residue is located at the C-terminal position. Prolidase has a unique function in all cell types; therefore, the mechanisms and parameters involved in prolidase activity regulation are of special interest. Could prolidase be a good biomarker in different physiologic and pathologic conditions? This is an important question. There is no consensus on the answer to this question. It is of great importance during collagen turnover, inflammation, tissue fibrosis and skeletal abnormalities.
Prolidase itself without other biochemical markers may not provide information to clinicians about disease activity. So, I think it should be evaluated together with other serum biochemical markers.
This review will serve to discuss many in vivo functions of prolidase, as well as level prolidase activity in diagnosis and monitoring of treatment in the various diseases (Ref. 50).

Keywords: prolidase, imidodipeptidase, proline dipeptidase
Published online: 10-Aug-2016
Year: 2016, Volume: 117, Issue: 8 Page From: 480, Page To: 485
doi:10.4149/BLL_2016_093


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