Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.9, p.530-538, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.117, No.9, p.530-538, 2016

Title: Effects of beta-glucan on protection of young and aged rats from renal ischemia and reperfusion injury
Author: M. Esrefoglu, O. E. Tok, M. S. Aydin, M. Iraz, O. F. Ozer, S. Selek, M. Iraz

Abstract: BACKGROUND: Ischemia–reperfusion injury is one of the leading causes of acute renal failure which is a common clinical event leading to development of chronic kidney disease and a high mortality; especially in elderly people. β-glucans are glucose polymer groups with free-radical scavenger, macrophage activator, and immune defense inducer functions. We designed this study to determine the possible protective effects of β-glucan against renal ischemia–reperfusion injury comparatively in young and aged rats.
METHODS: Rats were assigned to the following groups: Young and aged sham, young and aged ischemia–reperfusion, young and aged β-glucan, young and aged ischemia–reperfusion+β-glucan. At the end of the experiment, following collection of blood samples, rats were sacrificed and kidneys were removed for histopathological and biochemical examination.
RESULTS: Mean tissue histopathological damage scores of young β-glucan group was lower than that of young ischemia–reperfusion group, and of aged β-glucan group was lower than that of aged ischemia–reperfusion group. Urea and creatinine levels of young and aged of sham group and β-glucan administered groups were all lower than those of ischemia–reperfusion and β-glucan+ischemia–reperfusion groups. Oxidative stress indexes of ischemia–reperfusion groups were increased however ; oxidative stress indexes of β-glucan administered to young and aged rats were lower than those of ischemia–reperfusion groups.
CONCLUSIONS: We conclude that β-glucan is effective to protect kidneys from ischemia–reperfusion-induced oxidative damage, especially in young rats (Fig. 6, Ref. 45).

Keywords: oxidative damage, beta-glucan, ischemia and reperfusion, kidney, aged rat
Published online: 21-Sep-2016
Year: 2016, Volume: 117, Issue: 9 Page From: 530, Page To: 538
doi:10.4149/BLL_2016_105


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