Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.10, p.557-561, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.117, No.10, p.557-561, 2016

Title: Androgen deprivation therapy and cardiovascular complications
Author: Z. Poljak, I. Hulin, L. Maruscakova, A. Carter, B. Mladosievicova

Abstract: Cardiovascular complications associated with the use of antiandrogens have already been known for some time. Based on the results of the latest meta-analyses and clinical studies published in the last few years, the attention of the scientific community is focused on the deleterious cardiovascular effects of gonadotropine-releasing hormon agonists in context of the androgen deprivating therapy. The cardiac toxicity is a problem especially in patients with preexisting cardiovascular comorbidities. Increased arterial wall thickening along with endothelial dysfunction has been observed in patients with descreased androgens levels in the peripheral blood. The treatment with gonadotropine-releasing hormon agonists may disrupt the intracellular concentration of calcium ions and the contractile process and potentially result in pathological remodelling of heart. Here, we give several possible mechanisms of action of gonadotropine-releasing hormon agonists on the cardiovascular system that may be a potential explanation of the clinical observations (Ref. 44).

Keywords: androgen deprivation therapy, cardiovascular risk, gonadotropine-releasing hormon agonists, prostate cancer, testosterone
Published online: 07-Nov-2016
Year: 2016, Volume: 117, Issue: 10 Page From: 557, Page To: 561
doi:10.4149/BLL_2016_109


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