Home Acta Virologica 2016 Acta Virologica Vol.60, No.4, p.393-399, 2016

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.60, No.4, p.393-399, 2016

Title: Pathogenicity characteristics of an Iranian variant-2 (IS-1494) like infectious bronchitis virus in experimentally infected SPF chickens
Author: H. NAJAFI, A. GHALYANCHI LANGEROUDI, M. HASHEMZADEH, O. MADADGAR, V. KARIMI, R. K. FARAHANI, H. ABDOLLAHI, H. MAGHSOUDSLOO, P. SEIFOURI

Abstract: Avian infectious bronchitis (IB) is a major cause of economic loss to the poultry industry. IB virus primarily affects respiratory tract, but strains differ in their tropism for such other target organs as kidneys and alimentary tract. The objective of this study was to estimate the pathogenicity of an Iranian IB virus (IBV) variant (variant-2) which is one of the most prevalent isolates circulating in Iranian poultry farms. SPF chickens were intranasally inoculated with 104 EID50/0.1 ml of the virus. Sera, fecal swabs, and different tissue samples were collected on different days post infection. Clinical signs, gross pathology, and histological changes were recorded. The amount of virus genome was quantified in different tissues and feces using quantitative real-time PCR assay. The highest viral loads were detected in the feces and cecal tonsils. Real-time PCR results demonstrated variant-2 tropism for respiratory tract, digestive system and renal tissue that is due to its epitheliotropic nature. This is the first pathogenicity study of Iranian variant-2 virus. Based on histology observations and clinical signs this isolate was classified as a nephropathogenic IBV. Further knowledge of IBV pathogenesis permits to perform more effective prevention practice.

Keywords: avian infectious bronchitis; Iran; pathogenesis; nephropathogen; histopathology
Published online: 07-Dec-2016
Year: 2016, Volume: 60, Issue: 4 Page From: 393, Page To: 399
doi:10.4149/av_2016_04_393


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