Home General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.1, p.83–90, 2017

Journal info

Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

Aims and Scope
Editorial Info
Abstracting and Indexing
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.36, No.1, p.83–90, 2017

Title: Effects of low and high deprenyl dose on antioxidant enzyme activities in the adult rat brain
Author: Maria Lalkovicova, Frantiska Horvathova, Igor Sulla, Jozef Mihalik, Viera Danielisova


We evaluated the effects of low dose deprenyl (LDD, 0.0025 mg/kg per day) and high dose deprenyl (HDD, 0.25 mg/kg per day) treatment of male Wistar rats for 30 days on the activities of SOD and CAT in the cortex, striatum, and hippocampus. Total SOD and MnSOD activities were increased with LDD (p < 0.05) in the cortex (0.74 ± 0.03; 0.31 ± 0.02), striatum (0.75 ± 0.02; 0.27 ± 0.03) and CA1 region of the hippocampus (0.75 ± 0.02; 0.29 ± 0.03) compared to the control (0.53 ± 0.02; 0.15 ± 0.02), but reduced (p < 0.05) with HDD compared to the LDD group.

CAT activity was increased (p < 0.05) with LDD in the cortex (27.34 ± 3.11), striatum (22.22 ± 1.85), and hippocampal CA1 region (16.62 ± 2.15) compared to control (10.33 ± 1.01), while a decrease was induced by HDD in the striatum (9.85 ± 1.09) compared to LDD. There was a significant (p < 0.05) difference in number of Fluoro Jade B positive CA1 neurons induced by LDD (21.14 ± 2.85%) and HDD (12.61 ± 1.42%), as well as the number of NeuN positive CA1 neurons after LDD (183.35 ± 11.14 cells/mm) and HDD (238.45 ± 14.11 cells/mm (p < 0.05). Deprenyl showed a potential in improving the neurological outcome and reducing the oxidative damage.

Keywords: CAT, catalase; CuZnSOD, copper-zinc superoxide dismutase; DAB, diaminobenzidine; GPx, gluthatione peroxidase; HDD, high dose deprenyl; LDD, low dose deprenyl; MAO, monoamine oxidase; MnSOD, manganese superoxide dismutase; PBS, phosphate-buffered saline; SOD, superoxide dismutase
Published online: 28-Dec-2016
Year: 2017, Volume: 36, Issue: 1 Page From: 83, Page To: 90

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.