Home General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.1, p.99–108, 2017

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.36, No.1, p.99–108, 2017

Title: Cerebellar neurochemical and histopathological changes in rat model of Parkinson’s disease induced by intrastriatal injection of rotenone
Author: Yasser A. Khadrawy, Iman M. Mourad, Haitham S. Mohammed, Neveen A. Noor, Heba S. Aboul Ezz

Abstract: The aim of the present work was to investigate the neurochemical changes induced in the cerebellum of rat model of Parkinson’s disease (PD). Rats were divided into two groups; control and rat model of PD induced by the intrastriatal injection of rotenone. As compared to control, a significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate together with a significant decrease in the inhibitory amino acids, GABA, glycine and taurine were observed in the cerebellum of rat model of PD. This was associated with a significant increase in lipid peroxidation, nitric oxide and tumor necrosis factor-α and a significant decrease in reduced glutathione. A significant decrease in acetylcholinesterase and a significant increase in Na+,K+-ATPase were recorded in the cerebellum of rat model of PD. In addition the cerebellar sections from rat model of PD showed marked necrosis of Purkinje cells, irregular damaged cells, cytoplasmic shrinkage, necrosis and perineuronal vacuolation. The present results indicate that the disturbance in the balance between the excitatory and inhibitory amino acids may have a role in the pathogenesis of PD. According to the present neurochemical and histopathological changes, the cerebellum should be taken into consideration during the treatment of PD.

Keywords: Cerebellum — Parkinson’s disease — Amino acid neurotransmitters — Oxidative stress — Rats
Published online: 28-Dec-2016
Year: 2017, Volume: 36, Issue: 1 Page From: 99, Page To: 108

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