Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.2, p.112-117, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.118, No.2, p.112-117, 2017

Title: Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death
Author: I. Kara, H. K. Pampal, F. Yildirim, E. Dilekoz, G. Emmez, F. P. U. Gocun, M. Kocabiyik, C. B. Demirel

Abstract:

AIM: Increased intracranial pressure following trauma and subsequent possible development of brain death are important factors for morbidity and mortality due to ischemic changes. We aimed to establish the role of ischemic modified albumin (IMA) in the early diagnosis of the process, starting with increased intracranial pressure and ending with brain death.
MATERIALS AND METHODS: Eighteen Wistar-Albino rats were divided into three groups; control (CG, n = 6), increased intracranial pressure (ICPG, n = 6), and brain death (BDG, n = 6). Intracranial pressure elevation and brain death were constituted with the inflation of a balloon of a Fogarty catheter in the epidural space. In all three groups, blood samples were drawn before the procedure, and at minutes 150 and 240 for IMA and malondialdehyde (MDA) analysis.
RESULTS: Serum IMA levels at 150 and 240 minutes were higher in ICPG than in CG (p < 0.05).

IMA levels were similar in ICPG and BDG. Serum MDA levels at 150 and 240 minutes increased in ICPG and BDG groups compared to CG (p < 0.05). MDA levels were similar in ICP and BD groups.
CONCLUSION: IMA should be considered as a biochemical parameter in the process starting from increased intracranial pressure elevation and ending at brain death (Tab. 3, Fig. 5, Ref. 31).



Keywords: ischemic modified albumin, increased intracranial pressure, brain death
Published online: 16-Feb-2017
Year: 2017, Volume: 118, Issue: 2 Page From: 112, Page To: 117
doi:10.4149/BLL_2017_023


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