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Endocrine Regulations 2004 Endocrine Regulations Vol.38, p.29-38, 2004
Endocrine Regulations 2004 Endocrine Regulations Vol.38, p.29-38, 2004
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Endocrine Regulations Vol.38, p.29-38, 2004 |
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| Title: 1alfa,25-DIHYDROXYVITAMIN D3 INDUCIBLE TRANSCRIPTION FACTOR AND ITS ROLE IN THE VITAMIN D ACTION | ||
| Author: P. Nezbedova, J. Brtko | ||
| Abstract: Objectives. Vitamin D is considered multifunctional steroid hormone that modulates calcium homeostasis through actions predominantly in kidney, bone and the intestinal tract. Nuclear vitamin D receptor (VDR) is a specific nuclear protein, a member of steroid hormone receptor superfamily. The amino acid sequence of the VDR shows a significant homology with other members of the nuclear hormone receptor superfamily, including receptors for glucocorticoids (GR), oestrogen (ER), androgen (AR), progesteron (PR), thyroid hormone (T3R), retinoic acid (RAR), retinoid X (RXR) and over 150 orphan receptors. VDR is known to mediate the pleiotropic biological actions of 1a,25-dihydroxyvitamin D3 through its ability to modulate the expression of target genes. VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes. The VDR has been shown to associate with several additional molecules to form the active transcriptional complex required for gene regulation. The regulation of this ligand-activated cellular transcription factor occurs at both transcriptional and posttranslational levels. This article summarizes a variety of effects of 1a,25-dihydroxyvitamin D3, acting through its cognate nuclear receptor, and its use in chemotherapy and chemoprevention of cancer. |
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| Keywords: Vitamin D3 – Nuclear receptors – Mechanism of | ||
| Year: 2004, Volume: 38, Issue: | Page From: 29, Page To: 38 | |
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