Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.3, p.142-148, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.118, No.3, p.142-148, 2017

Title: Turmeric extract inhibits apoptosis of hippocampal neurons of trimethyltin-exposed rats
Author: S. Yuliani, S. Widyarini, Mustofa, G. Partadiredja

Abstract: OBJECTIVES: The aim of the present study was to reveal the possible antiapoptotic effect of turmeric (Curcuma longa Linn.) on the hippocampal neurons of rats exposed to trimethyltin (TMT).
BACKGROUND: Oxidative damage in the hippocampus can induce the apoptosis of neurons associated with the pathogenesis of dementia
METHODS. The ethanolic turmeric extract and a citicoline (as positive control) solution were administered to the TMT-exposed rats for 28 days. The body weights of rats were recorded once a week. The hippocampal weights and imumunohistochemical expression of caspase 3 proteins in the CA1 and CA2-CA3 regions of the hippocampi were examined at the end of the experiment.
RESULTS: Immunohistochemical analysis showed that the injection of TMT increased the expression of caspase 3 in the CA1 and CA2-CA3 regions of hippocampus. TMT also decreased the body and hippocampal weights. Furthermore, the administration of 200 mg/kg bw dose of turmeric extract decreased the caspase 3 expression in the CA2-CA3 pyramidal neurons but not in the CA1 neurons. It also prevented the decrease of the body and hippocampal weights.
CONCLUSION: We suggest that the 200 mg/kg bw dose of turmeric extract may exert antiapoptotic effect on the hippocampal neurons of the TMT-exposed rats (Tab. 1, Fig. 3, Ref. 49).

Keywords: turmeric, hippocampus, trimethyltin, caspase 3, immunohistochemistry
Published online: 14-Mar-2017
Year: 2017, Volume: 118, Issue: 3 Page From: 142, Page To: 148
doi:10.4149/BLL_2017_028


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