Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.3, p.149-152, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.118, No.3, p.149-152, 2017

Title: Investigation of anticarcinogenic and antioxidant effects of -methylimidazole
Author: M. Norizadeh Tazehkand, O. Hajipour, F. Moridikia, A. Moridikia, E. Valipour, M. B. Yilmaz, M. Topaktas
Abstract: 4-methylimidazole is widely used in pharmaceuticals, photographic and agricultural chemicals. The substance is extensively found in many human and animals foods. In this research, anticancer effect of the 4-MEI was studded using MTT test using MCF-7 cell line. Effect of the 4-MEI on apoptosis or necrosis was analyzed by DNA fragmentation assay using Swiss Albino rats as a model organism. Antioxidant effect of the substance was investigated by assaying protective effect of the substance on circular plasmid DNA against H2O2 as an oxidative agent.
4-MEI showed inhibitory effect on proliferation of MCF-7 cell line by all concentrations and the decrement was significant and concentration dependent. Result of DNA fragmentation assay showed 4-MEI concentrations dependent of smear formation showing necrotic effects of the 4-MEI on mouse cells. Also, the 4-MEI showed a good antioxidant activity and protective effect against H2O2.
CONCLUSION: The result of this study showed that 4MEI has significant antioxidant and anti-cancer effect. Also, according to the result, 4-MEI has necrotic effects on mouse cells (Fig. 3, Ref. 21).
Keywords: 4-MEI, MCF-7, fragmentation, antioxidant, anticancer
Published online: 14-Mar-2017
Year: 2017, Volume: 118, Issue: 3 Page From: 149, Page To: 152
doi:10.4149/BLL_2017_029


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